Ki Summary

Reaction Details

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Target

Vasoactive intestinal polypeptide receptor 2

Ligand

BDBM85873

Substrate

n/a

3.5±n/a nM

Comments

PDSP_2124

Citation

Igarashi, H; Ito, T; Pradhan, TK; Mantey, SA; Hou, W; Coy, DH; Jensen, RT Elucidation of the vasoactive intestinal peptide pharmacophore for VPAC(2) receptors in human and rat and comparison to the pharmacophore for VPAC(1) receptors. J Pharmacol Exp Ther 303:445-60 (2002) [PubMed] Article

More Info.:

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Target

Name:

Vasoactive intestinal polypeptide receptor 2

Synonyms:

VIP 2 | VIP2R | VIPR2 | VIPR2_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49488.30

Organism:

Homo sapiens (Human)

Description:

VIP 2 VIPR2 HUMAN::P41587

Residue:

438

Sequence:

MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI

Inhibitor

Name:

BDBM85873

Synonyms:

VIP Ala2

Type:

Small organic molecule

Emp. Form.:

C147H240N44O40S

Mol. Mass.:

3295.814

SMILES:

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Structure: