Reaction Details
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Report a problem with these dataTarget
Muscarinic acetylcholine receptor M1
Ligand
BDBM277250
Substrate
n/a
Meas. Tech.
In Vitro Cellular Assay
Temperature
298.15±n/a K
EC50
10.0±n/a nM
Comments
extracted
Citation
Payne, A; Castro Pineiro, JL; Birch, LM; Khan, A; Braunton, AJ; Kitulagoda, JE; Soejima, M 4-azaindole derivatives US Patent US10072005 Publication Date 9/11/2018 More Info.:
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
Inhibitor
Name:
BDBM277250
Synonyms:
US10072005, Example 43
Type:
Small organic molecule
Emp. Form.:
C25H28N5O2
Mol. Mass.:
430.5221
SMILES:
C[N]1=CNC(=C1)c1ccc(Cn2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c3ncccc23)cc1 |r,c:4,t:1|
Structure:
