Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM277307
Substrate
n/a
Meas. Tech.
In Vitro Cellular Assay
Temperature
298.15±n/a K
EC50
158±n/a nM
Comments
extracted
Citation
 Payne, A; Castro Pineiro, JL; Birch, LM; Khan, A; Braunton, AJ; Kitulagoda, JE; Soejima, M 4-azaindole derivatives US Patent  US10072005 Publication Date 9/11/2018 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM277307
Synonyms:
US10072005, Example 100
Type:
Small organic molecule
Emp. Form.:
C23H24F3N3O3
Mol. Mass.:
447.4502
SMILES:
Cc1ccnc2c(cn(Cc3ccc(OC(F)(F)F)cc3)c12)C(=O)N[C@H]1CCCC[C@@H]1O |r|
Structure:
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