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Target
Potassium voltage-gated channel subfamily H member 8
Ligand
BDBM50022784
Substrate
n/a
Ki
1000±n/a nM
Comments
PDSP_3689
Citation
 Bymaster, FP; Katner, JS; Nelson, DL; Hemrick-Luecke, SK; Threlkeld, PG; Heiligenstein, JH; Morin, SM; Gehlert, DR; Perry, KW Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27:699-711 (2002) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily H member 8
Synonyms:
Elk1 | Elk3 | KCNH8_RAT | Kcnh8 | Potassium Channel | Potassium voltage-gated channel subfamily H member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
123234.95
Organism:
RAT
Description:
Q9QWS8
Residue:
1102
Sequence:
MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRAKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVPQAEPKGNGSIKKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSSKSYLGLSLKQLTSGTVPFHSPIRVSSANSPKTKQEADPPNHGTRKEKNLKVQLCSLGTAGTPELSPRIVDGIEDGNSSEETQTFDFGSEQIRPEPRISPSLGESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRSIMQLLENILSPQQPSQFCSLHPTSICPSRESFQTRVSWSAHQPCLHLQANGAHLYHGNVTSDIWSVDPSLVGSNPQRTEAHEQSPVDSELHHSPNLAYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREGMMSASTEPLENFPVEVVTSTADVKDSKAINV
  
Inhibitor
Name:
BDBM50022784
Synonyms:
(R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine | ATOMOXETINE | CHEMBL641 | Methyl-((R)-3-phenyl-3-o-tolyloxy-propyl)-amine | Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine | Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxetine) | Strattera | Tomoxetine
Type:
Small organic molecule
Emp. Form.:
C17H21NO
Mol. Mass.:
255.3547
SMILES:
CNCCC(Oc1ccccc1C)c1ccccc1
Structure:
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