Reaction Details Report a problem with these data
Target
Histamine receptor H3
Ligand
BDBM27213
Substrate
n/a
Ki
5.75±n/a nM
Comments
PDSP_2989
Citation
 Esbenshade, TA; Krueger, KM; Miller, TR; Kang, CH; Denny, LI; Witte, DG; Yao, BB; Fox, GB; Faghih, R; Bennani, YL; Williams, M; Hancock, AA Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. J Pharmacol Exp Ther 305:887-96 (2003) [PubMed]  Article 
Target
Name:
Histamine receptor H3
Synonyms:
HISTAMINE H3 | HRH3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
16901.59
Organism:
Dog
Description:
Q865E3
Residue:
147
Sequence:
FLLNLAISDFLVGAFCIPLYVPYVLTGRWPFSRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVQKMVLVWVLAFLLYGPAILSWEHLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFN
  
Inhibitor
Name:
BDBM27213
Synonyms:
4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole | CHEMBL14638 | CHEMBL1795025 | Ciproxifan
Type:
Small organic molecule
Emp. Form.:
C16H18N2O2
Mol. Mass.:
270.3263
SMILES:
O=C(C1CC1)c1ccc(OCCCc2cnc[nH]2)cc1
Structure:
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