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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM164136
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Temperature
277.15±n/a K
Ki
5.00±n/a nM
Comments
extracted
Citation
 Coate, HR; Dvorak, CA; Lebold, TP; Preville, C; Shireman, BT Substituted 7-azabicycles and their use as orexin receptor modulators US Patent  US9695183 Publication Date 7/4/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:
Protein
Mol. Mass.:
46817.55
Organism:
Rattus norvegicus (Rat)
Description:
P56718
Residue:
416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
  
Inhibitor
Name:
BDBM164136
Synonyms:
US9062078, 266 | US9475819, 266 | US9637496, 409 | US9695183, 266
Type:
Small organic molecule
Emp. Form.:
C22H20F3N5O2
Mol. Mass.:
443.4217
SMILES:
Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 |TLB:15:13:11.10:8|
Structure:
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