Reaction Details Report a problem with these data
Target
Retinol-binding protein 4
Ligand
BDBM249503
Substrate
n/a
Meas. Tech.
TR-FRET Assay for Retinol-induced RBP4-TTR Interaction
pH
7.5±n/a
IC50
7.44±n/a nM
Comments
extracted
Citation
 Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent  US10072016 Publication Date 9/11/2018 
Target
Name:
Retinol-binding protein 4
Synonyms:
PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4
Type:
Protein
Mol. Mass.:
23008.75
Organism:
Homo sapiens (Human)
Description:
P02753
Residue:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM249503
Synonyms:
US10072016, Compound 101 | US10407433, Compound 101 | US10913746, Compound 101 | US11649240, Compound 101 | US9434727, 101 | US9777010, Compound 101
Type:
Small organic molecule
Emp. Form.:
C20H19F5N4O3
Mol. Mass.:
458.3819
SMILES:
COC(=O)N1Cc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)c(F)c3C(F)(F)F)c2C1
Structure:
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