Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM249538
Substrate
n/a
Meas. Tech.
Scintillation Proximity RBP4 Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
12.0±n/a nM
Comments
extracted
Citation
 Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent  US10072016 Publication Date 9/11/2018 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM249538
Synonyms:
US10072016, Compound 136 | US10407433, Compound 136 | US10913746, Compound 136 | US11649240, Compound 136 | US9434727, 136 | US9777010, Compound 136
Type:
Small organic molecule
Emp. Form.:
C20H18F5N5O
Mol. Mass.:
439.3818
SMILES:
Fc1cc(F)c(c(c1)C1CCN(CC1)C(=O)c1n[nH]c2CN(CCc12)C#N)C(F)(F)F
Structure:
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