Reaction Details
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5-hydroxytryptamine receptor 6
Ligand
BDBM50090528
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_3221
Citation
Hirst, WD; Abrahamsen, B; Blaney, FE; Calver, AR; Aloj, L; Price, GW; Medhurst, AD Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol Pharmacol 64:1295-308 (2003) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_MOUSE | Htr6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47012.98
Organism:
MOUSE
Description:
5-HT6 HTR6 MOUSE::Q9R1C8
Residue:
440
Sequence:
MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNFFVTDSVEPEIRQHPLGSPMN
Inhibitor
Name:
BDBM50090528
Synonyms:
4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-benzenesulfonamide | 4-Amino-N-(2,6-bis-methylamino-pyrimidin-4-yl)-benzenesulfonamide | 4-Amino-N-(2-methylamino-pyrimidin-4-yl)-benzenesulfonamide | 4-amino-N-(2,6-bis(methylamino)pyrimidin-4-yl)benzenesulfonamide | CHEMBL433461 | N-(2,6-bis(methylamino)pyrimidin-4-yl)-4-aminobenzenesulfonamide | Ro 04-6790 | Ro-04-6790
Type:
Small organic molecule
Emp. Form.:
C12H16N6O2S
Mol. Mass.:
308.359
SMILES:
CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC)n1
Structure:
