Reaction Details Report a problem with these data
Target
Hrh3 protein
Ligand
BDBM50159110
Substrate
n/a
Ki
1.26±n/a nM
Comments
PDSP_3762
Citation
Barbier, AJ; Berridge, C; Dugovic, C; Laposky, AD; Wilson, SJ; Boggs, J; Aluisio, L; Lord, B; Mazur, C; Pudiak, CM; Langlois, X; Xiao, W; Apodaca, R; Carruthers, NI; Lovenberg, TW Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol 143:649-61 (2004) [PubMed] Article
More Info.:
Target
Name:
Hrh3 protein
Synonyms:
HISTAMINE H3 | HRH3 | Hrh3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37860.96
Organism:
RAT
Description:
Q5PPG3
Residue:
344
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDY
Inhibitor
Name:
BDBM50159110
Synonyms:
1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piperidine | 1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine | 1-[3-(4-hexahydro-1-pyridinylmethylphenoxy)propyl]hexahydropyridine | 1-[4-(3-hexahydro-1-pyridinylpropoxy)benzyl]hexahydropyridine | CHEMBL129542 | JNJ-5207852
Type:
Small organic molecule
Emp. Form.:
C20H32N2O
Mol. Mass.:
316.4809
SMILES:
C(COc1ccc(CN2CCCCC2)cc1)CN1CCCCC1