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Target
Mitogen-activated protein kinase 9
Ligand
BDBM86637
Substrate
n/a
Meas. Tech.
JNK Kinase Assay
IC50
11.3±0.0 nM
Citation
 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Discovery of potent and selective covalent inhibitors of JNK. Chem Biol 19:140-54 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
  
Inhibitor
Name:
BDBM86637
Synonyms:
JNK-IN-12
Type:
Small organic molecule
Emp. Form.:
C32H28N8O2S
Mol. Mass.:
588.682
SMILES:
CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Structure:
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