Reaction Details
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Report a problem with these dataTarget
cAMP-dependent protein kinase catalytic subunit beta
Ligand
BDBM86727
Substrate
n/a
Ki
3000±n/a nM
Comments
PDSP_6134
Citation
Braverman, AS; Tibb, AS; Ruggieri, MR M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder. J Pharmacol Exp Ther 316:869-74 (2006) [PubMed] Article More Info.:
Target
Name:
cAMP-dependent protein kinase catalytic subunit beta
Synonyms:
KAPCB_RAT | PKA | Pkacb | Prkacb | cAMP-dependent protein kinase catalytic subunit beta
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40715.41
Organism:
RAT
Description:
PKA 0 RAT::P68182
Residue:
351
Sequence:
MGNTAIAKKGSEVESVKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF
Inhibitor
Name:
BDBM86727
Synonyms:
1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2HCl | CAS_140663-38-3
Type:
Small organic molecule
Emp. Form.:
C14H17N3O2S
Mol. Mass.:
291.369
SMILES:
CC1CN(CCN1)S(=O)(=O)c1cccc2cnccc12
Structure:
