Reaction Details Report a problem with these data
Target
Glutathione-disulfide reductase
Ligand
BDBM87062
Substrate
n/a
Meas. Tech.
Enzyme Assay
Ki
6100±1400 nM
IC50
4500±0.0 nM
Citation
 Bülbül, M; Erat, M Investigation of the effects of some sulfonamide derivatives on the activities of glucose-6-phosphate dehydrogenase, 6-phospho gluconate dehydrogenase and glutathione reductase from human erythrocytes. J Enzyme Inhib Med Chem 23:418-23 (2008) [PubMed]  Article 
Target
Name:
Glutathione-disulfide reductase
Synonyms:
Glutathione oxidoreductase (GR)
Type:
Protein
Mol. Mass.:
48732.90
Organism:
Escherichia coli
Description:
A0A0H3JIZ9
Residue:
450
Sequence:
MTKHYDYIAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIREAIHMYGPDYGFDTTINKFNWETLIASRTAYIDRIHTSYENVLGKNNVDVIKGFARFVDAKTLEVNGETITADHILIATGGRPSHPDIPGVEYGIDSDGFFALPALPERVAVVGAGYIAVELAGVINGLGAKTHLFVRKHAPLRSFDPMISETLVEVMNAEGPQLHTNAIPKAVVKNADGSLTLELEDGRSETVDCLIWAIGREPANDNINLEAAGVKTNEKGYIVVDKYQNTNVEGIYAVGDNTGAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTVGLTEPQAREQYGDDQVKVYKSSFTAMYTAVTTHRQPCRMKLVCVGPEEKIVGIHGIGFGMDEMLQGFAVALKMGATKKDFDNTVAIHPTAAEEFVTMR
  
Inhibitor
Name:
BDBM87062
Synonyms:
Sulfonamide derivative, 2
Type:
Small organic molecule
Emp. Form.:
C26H42N4O5S2
Mol. Mass.:
554.765
SMILES:
CC(CCC(=O)Nc1nnc(s1)S(N)(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C
Structure:
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