Reaction Details
Report a problem with these data
Report a problem with these dataTarget
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM61352
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
8670±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM61352
Synonyms:
5-methyl-6-oxo-3-benzo[b][1,4]benzothiazepinecarboxylic acid ethyl ester | 6-keto-5-methyl-benzo[b][1,4]benzothiazepine-3-carboxylic acid ethyl ester | MLS001200939 | SMR000564429 | cid_4068244 | ethyl 10-methyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate | ethyl 5-methyl-6-oxidanylidene-benzo[b][1,4]benzothiazepine-3-carboxylate | ethyl 5-methyl-6-oxobenzo[b][1,4]benzothiazepine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H15NO3S
Mol. Mass.:
313.371
SMILES:
CCOC(=O)c1ccc2Sc3ccccc3C(=O)N(C)c2c1
Structure:
