Target
Tegument protein VP16
Ligand
BDBM87261
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
24242±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87261
Synonyms:
MLS000554094 | N'-(4-Cyano-5-ethyl-5H-pyrido[4,3-b]indol-3-yl)-N,N-dimethyl-formamidine | N'-(4-cyano-5-ethyl-3-pyrido[4,3-b]indolyl)-N,N-dimethylmethanimidamide | N'-(4-cyano-5-ethyl-pyrid[4,3-b]indol-3-yl)-N,N-dimethyl-formamidine | N'-(4-cyano-5-ethyl-pyrido[4,3-b]indol-3-yl)-N,N-dimethyl-methanimidamide | N'-(4-cyano-5-ethylpyrido[4,3-b]indol-3-yl)-N,N-dimethylmethanimidamide | SMR000146411 | cid_3707292
Type:
Small organic molecule
Emp. Form.:
C17H17N5
Mol. Mass.:
291.3504
SMILES:
CCn1c2ccccc2c2cnc(\N=C\N(C)C)c(C#N)c12
Structure:
Search PDB for entries with ligand similarity: