Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87274
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
6590±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87274
Synonyms:
2-(N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-cyclohexyl-2-(4-methoxyphenyl)acetamide | 2-(N-(2-chloroacetyl)-4-methoxy-anilino)-N-cyclohexyl-2-(4-methoxyphenyl)acetamide | 2-(N-(2-chloroacetyl)-4-methoxyanilino)-N-cyclohexyl-2-(4-methoxyphenyl)acetamide | 2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide | 2-[2-chloranylethanoyl-(4-methoxyphenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)ethanamide | MLS000583961 | SMR000206947 | cid_12004951
Type:
Small organic molecule
Emp. Form.:
C24H29ClN2O4
Mol. Mass.:
444.951
SMILES:
COc1ccc(cc1)C(N(C(=O)CCl)c1ccc(OC)cc1)C(=O)NC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: