BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAlpha trans-inducing protein (VP16)
LigandBDBM51762
Substrate/Competitorn/a
Meas. Tech.Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50 14533±n/a nM
Citation PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay(2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
Alpha trans-inducing protein (VP16)
Name:Alpha trans-inducing protein (VP16)
Synonyms:transactivating tegument protein VP16
Type:PROTEIN
Mol. Mass.:54325.13
Organism:Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:EBI_100271
Residue:490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAA
LFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYV
PERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALY
RYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILW
AAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIRE
HLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMR
EHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSL
GDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFT
DALGIDEYGG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM51762
NameBDBM51762
Synonyms:IRINOTECAN HCl )trihydrate) | MLS001401366 | SMR000469166 | cid_23581792
TypeSmall organic molecule
Emp. Form.C33H41ClN4O7
Mol. Mass.641.154
SMILESO.Cl.CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a