Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM39009
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
11653±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM39009
Synonyms:
6-(4-bromophenyl)-2-(methylsulfinyl)-4-phenylnicotinonitrile | 6-(4-bromophenyl)-2-methylsulfinyl-4-phenyl-3-pyridinecarbonitrile | 6-(4-bromophenyl)-2-methylsulfinyl-4-phenyl-nicotinonitrile | 6-(4-bromophenyl)-2-methylsulfinyl-4-phenyl-pyridine-3-carbonitrile | 6-(4-bromophenyl)-2-methylsulfinyl-4-phenylpyridine-3-carbonitrile | MLS000048185 | SMR000073426 | cid_1316704
Type:
Small organic molecule
Emp. Form.:
C19H13BrN2OS
Mol. Mass.:
397.288
SMILES:
CS(=O)c1nc(cc(-c2ccccc2)c1C#N)-c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: