Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM87670
Substrate
n/a
Meas. Tech.
Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay
IC50
>66000±n/a nM
Citation
 PubChem, PC Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM87670
Synonyms:
4-[(3,4-dimethylbenzoyl)amino]-2,3-dihydrothiophene-5-carboxylic acid methyl ester | 4-[[(3,4-dimethylphenyl)-oxomethyl]amino]-2,3-dihydrothiophene-5-carboxylic acid methyl ester | MLS000087767 | SMR000023987 | cid_3242715 | methyl 3-[(3,4-dimethylbenzoyl)amino]-4,5-dihydrothiophene-2-carboxylate | methyl 4-[(3,4-dimethylbenzoyl)amino]-2,3-dihydrothiophene-5-carboxylate | methyl 4-[(3,4-dimethylphenyl)carbonylamino]-2,3-dihydrothiophene-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C15H17NO3S
Mol. Mass.:
291.365
SMILES:
COC(=O)C1=C(CCS1)NC(=O)c1ccc(C)c(C)c1 |t:4|
Structure:
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