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Target
Polyadenylate-binding protein 1
Ligand
BDBM87680
Substrate
n/a
Meas. Tech.
Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay
IC50
>66000±n/a nM
Citation
 PubChem, PC Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM87680
Synonyms:
2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-N-(5-methyl-1,2-oxazol-3-yl)acetamide | 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-N-(5-methyl-1,2-oxazol-3-yl)ethanamide | 2-(4,5-dihydro-1,3-thiazol-2-ylthio)-N-(5-methyl-3-isoxazolyl)acetamide | 2-(4,5-dihydrothiazol-2-ylthio)-N-(5-methyl-3-isoxazolyl)acetamide | MLS000062650 | N-(5-methylisoxazol-3-yl)-2-(2-thiazolin-2-ylthio)acetamide | SMR000071187 | cid_845171
Type:
Small organic molecule
Emp. Form.:
C9H11N3O2S2
Mol. Mass.:
257.333
SMILES:
Cc1cc(NC(=O)CSC2=NCCS2)no1 |t:9|
Structure:
Search PDB for entries with ligand similarity: