Target
Delta-type opioid receptor
Ligand
BDBM88433
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>92470±n/a nM
Citation
 PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM88433
Synonyms:
(E)-2-cyano-N-(2-furanylmethyl)-3-[1-(2-phenoxyethyl)-3-indolyl]-2-propenamide | (E)-2-cyano-N-(2-furfuryl)-3-[1-(2-phenoxyethyl)indol-3-yl]acrylamide | (E)-2-cyano-N-(furan-2-ylmethyl)-3-[1-(2-phenoxyethyl)indol-3-yl]prop-2-enamide | 2-Cyano-N-furan-2-ylmethyl-3-[1-(2-phenoxy-ethyl)-1H-indol-3-yl]-acrylamide | MLS000557673 | SMR000177357 | cid_5765807
Type:
Small organic molecule
Emp. Form.:
C25H21N3O3
Mol. Mass.:
411.4525
SMILES:
O=C(NCc1ccco1)C(=C\c1cn(CCOc2ccccc2)c2ccccc12)\C#N
Structure:
Search PDB for entries with ligand similarity: