Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM88439
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>64580±n/a nM
Citation
PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID]
More Info.:
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
Inhibitor
Name:
BDBM88439
Synonyms:
5-(4-chlorophenyl)-N-[(2-hydroxy-4-methyl-phenyl)thiocarbamoyl]-2-furamide | 5-(4-chlorophenyl)-N-[(2-hydroxy-4-methylanilino)-sulfanylidenemethyl]-2-furancarboxamide | 5-(4-chlorophenyl)-N-[(2-hydroxy-4-methylphenyl)carbamothioyl]furan-2-carboxamide | 5-(4-chlorophenyl)-N-[(4-methyl-2-oxidanyl-phenyl)carbamothioyl]furan-2-carboxamide | 5-(4-chlorophenyl)-N-{[(2-hydroxy-4-methylphenyl)amino]carbonothioyl}-2-furamide | MLS000574087 | SMR000195672 | cid_1048268
Type:
Small organic molecule
Emp. Form.:
C19H15ClN2O3S
Mol. Mass.:
386.852
SMILES:
Cc1ccc(NC(=S)NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)c(O)c1