Target
Delta-type opioid receptor
Ligand
BDBM88447
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>92442±n/a nM
Citation
 PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM88447
Synonyms:
(E)-2-cyano-3-[1-[2-(2-fluoranylphenoxy)ethyl]indol-3-yl]-N-(thiophen-2-ylmethyl)prop-2-enamide | (E)-2-cyano-3-[1-[2-(2-fluorophenoxy)ethyl]-3-indolyl]-N-(thiophen-2-ylmethyl)-2-propenamide | (E)-2-cyano-3-[1-[2-(2-fluorophenoxy)ethyl]indol-3-yl]-N-(2-thenyl)acrylamide | (E)-2-cyano-3-[1-[2-(2-fluorophenoxy)ethyl]indol-3-yl]-N-(thiophen-2-ylmethyl)prop-2-enamide | 2-Cyano-3-{1-[2-(2-fluoro-phenoxy)-ethyl]-1H-indol-3-yl}-N-thiophen-2-ylmethyl-acrylamide | MLS000563936 | SMR000177627 | cid_1132167
Type:
Small organic molecule
Emp. Form.:
C25H20FN3O2S
Mol. Mass.:
445.509
SMILES:
Fc1ccccc1OCCn1cc(\C=C(/C#N)C(=O)NCc2cccs2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: