Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM88458
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>64593±n/a nM
Citation
PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID]
More Info.:
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
Inhibitor
Name:
BDBM88458
Synonyms:
2-[[[1-(4-chlorophenyl)-5-benzotriazolyl]amino]methylidene]propanedioic acid diethyl ester | 2-[[[1-(4-chlorophenyl)benzotriazol-5-yl]amino]methylene]malonic acid diethyl ester | MLS000698359 | SMR000224928 | cid_1827509 | diethyl 2-({[1-(4-chlorophenyl)-1H-1,2,3-benzotriazol-5-yl]amino}methylene)malonate | diethyl 2-[[[1-(4-chlorophenyl)benzotriazol-5-yl]amino]methylidene]propanedioate
Type:
Small organic molecule
Emp. Form.:
C20H19ClN4O4
Mol. Mass.:
414.842
SMILES:
[#6]-[#6]-[#8]-[#6](=O)-[#6](=[#6]\[#7]-c1ccc2n(nnc2c1)-c1ccc(Cl)cc1)\[#6](=O)-[#8]-[#6]-[#6]