Target
Delta-type opioid receptor
Ligand
BDBM88473
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>92554±n/a nM
Citation
 PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM88473
Synonyms:
4-[4-[(2-chloranyl-6-fluoranyl-phenyl)methoxy]phenyl]pyrimidin-2-amine | 4-[4-[(2-chloro-6-fluorophenyl)methoxy]phenyl]-2-pyrimidinamine | 4-[4-[(2-chloro-6-fluorophenyl)methoxy]phenyl]pyrimidin-2-amine | 4-{4-[(2-chloro-6-fluorobenzyl)oxy]phenyl}-2-pyrimidinamine | MLS000721597 | SMR000335908 | [4-[4-(2-chloro-6-fluoro-benzyl)oxyphenyl]pyrimidin-2-yl]amine | cid_1472403
Type:
Small organic molecule
Emp. Form.:
C17H13ClFN3O
Mol. Mass.:
329.756
SMILES:
Nc1nccc(n1)-c1ccc(OCc2c(F)cccc2Cl)cc1
Structure:
Search PDB for entries with ligand similarity: