Target
Delta-type opioid receptor
Ligand
BDBM88490
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>64568±n/a nM
Citation
 PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM88490
Synonyms:
1-[2-[2-(4-methoxyphenyl)-5-(4-morpholinyl)-1-benzothiophen-3-yl]ethynyl]-1-cyclohexanol | 1-[2-[2-(4-methoxyphenyl)-5-morpholin-4-yl-1-benzothiophen-3-yl]ethynyl]cyclohexan-1-ol | 1-[2-[2-(4-methoxyphenyl)-5-morpholino-benzothiophen-3-yl]ethynyl]cyclohexanol | MLS002473545 | SMR001397713 | cid_44202203
Type:
Small organic molecule
Emp. Form.:
C27H29NO3S
Mol. Mass.:
447.589
SMILES:
COc1ccc(cc1)-c1sc2ccc(cc2c1C#CC1(O)CCCCC1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: