Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM88521
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>92449±n/a nM
Citation
PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID]
More Info.:
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
Inhibitor
Name:
BDBM88521
Synonyms:
4-[1-amino-2-[4-(trifluoromethyl)phenyl]ethyl]-N-[4-(trifluoromethyl)-2-pyrimidinyl]-2-thiazolamine | 4-[1-amino-2-[4-(trifluoromethyl)phenyl]ethyl]-N-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3-thiazol-2-amine | 4-[1-azanyl-2-[4-(trifluoromethyl)phenyl]ethyl]-N-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3-thiazol-2-amine | MLS003123761 | SMR001291818 | [4-[1-amino-2-[4-(trifluoromethyl)phenyl]ethyl]thiazol-2-yl]-[4-(trifluoromethyl)pyrimidin-2-yl]amine | cid_46948222
Type:
Small organic molecule
Emp. Form.:
C17H13F6N5S
Mol. Mass.:
433.374
SMILES:
NC(Cc1ccc(cc1)C(F)(F)F)c1csc(Nc2nccc(n2)C(F)(F)F)n1