Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM88736
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay
IC50
3650±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM88736
Synonyms:
MLS000584580 | N-(3-chloranyl-4-methoxy-phenyl)-4-[methyl(oxolan-2-ylmethyl)amino]piperidine-1-carbothioamide | N-(3-chloro-4-methoxy-phenyl)-4-[methyl(tetrahydrofurfuryl)amino]piperidine-1-carbothioamide | N-(3-chloro-4-methoxyphenyl)-4-[methyl(2-oxolanylmethyl)amino]-1-piperidinecarbothioamide | N-(3-chloro-4-methoxyphenyl)-4-[methyl(oxolan-2-ylmethyl)amino]piperidine-1-carbothioamide | N-(3-chloro-4-methoxyphenyl)-4-[methyl(tetrahydrofuran-2-ylmethyl)amino]piperidine-1-carbothioamide | SMR000207165 | cid_4112942
Type:
Small organic molecule
Emp. Form.:
C19H28ClN3O2S
Mol. Mass.:
397.963
SMILES:
COc1ccc(NC(=S)N2CCC(CC2)N(C)CC2CCCO2)cc1Cl
Structure:
Search PDB for entries with ligand similarity: