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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM88818
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
21600±1790 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM88818
Synonyms:
MLS000036693 | N'-[3-cyano-1-(2-furanylmethyl)-4,5-diphenyl-2-pyrrolyl]-N,N-dimethylmethanimidamide | N'-[3-cyano-1-(2-furfuryl)-4,5-diphenyl-pyrrol-2-yl]-N,N-dimethyl-formamidine | N'-[3-cyano-1-(furan-2-ylmethyl)-4,5-diphenyl-pyrrol-2-yl]-N,N-dimethyl-methanimidamide | N'-[3-cyano-1-(furan-2-ylmethyl)-4,5-diphenylpyrrol-2-yl]-N,N-dimethylmethanimidamide | SMR000042300 | cid_9568661
Type:
Small organic molecule
Emp. Form.:
C25H22N4O
Mol. Mass.:
394.4684
SMILES:
CN(C)\C=N\c1c(C#N)c(c(-c2ccccc2)n1Cc1ccco1)-c1ccccc1
Structure:
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