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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM47086
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
17600±1020 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM47086
Synonyms:
2-(3-methylanilino)-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one | 2-(m-toluidino)-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one | 2-[(3-methylphenyl)amino]-5H-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one | 2-[(3-methylphenyl)amino]-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one | MLS000095263 | SMR000030817 | cid_3238944
Type:
Small organic molecule
Emp. Form.:
C16H12N4OS
Mol. Mass.:
308.358
SMILES:
Cc1cccc(Nc2nn3c(nc4ccccc4c3=O)s2)c1
Structure:
Search PDB for entries with ligand similarity: