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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM88829
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
5140±1040 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM88829
Synonyms:
4-[(E)-(1-butyl-2-benzimidazolyl)iminomethyl]-N,N-dimethylaniline | 4-[(E)-(1-butylbenzimidazol-2-yl)iminomethyl]-N,N-dimethyl-aniline | 4-[(E)-(1-butylbenzimidazol-2-yl)iminomethyl]-N,N-dimethylaniline | MLS000549030 | N-(1-butyl-1H-benzimidazol-2-yl)-N-[4-(dimethylamino)benzylidene]amine | SMR000113954 | [4-[(E)-(1-butylbenzimidazol-2-yl)iminomethyl]phenyl]-dimethyl-amine | cid_9634351
Type:
Small organic molecule
Emp. Form.:
C20H24N4
Mol. Mass.:
320.4314
SMILES:
CCCCn1c(\N=C\c2ccc(cc2)N(C)C)nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: