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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM88830
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
23900±2210 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM88830
Synonyms:
2-(6-quinolinyl)benzo[de]isoquinoline-1,3-dione | 2-(6-quinolyl)benzo[de]isoquinoline-1,3-quinone | 2-Quinolin-6-yl-benzo[de]isoquinoline-1,3-dione | 2-quinolin-6-ylbenzo[de]isoquinoline-1,3-dione | MLS000120880 | SMR000118311 | cid_2055089
Type:
Small organic molecule
Emp. Form.:
C21H12N2O2
Mol. Mass.:
324.3322
SMILES:
O=C1N(C(=O)c2cccc3cccc1c23)c1ccc2ncccc2c1
Structure:
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