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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM88831
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
14600±1630 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM88831
Synonyms:
3-[3-chloranyl-5-(trifluoromethyl)pyridin-2-yl]sulfanyl-5-[(2Z)-2-[(4-methylphenyl)methoxyimino]ethyl]-1,2-thiazole-4-carbonitrile | 3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl-5-[(2Z)-2-[(4-methylphenyl)methoxyimino]ethyl]-1,2-thiazole-4-carbonitrile | 3-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]thio]-5-[(2Z)-2-[(4-methylphenyl)methoxyimino]ethyl]-4-isothiazolecarbonitrile | 3-[[3-chloro-5-(trifluoromethyl)-2-pyridyl]thio]-5-[(2Z)-2-(4-methylbenzyl)oximinoethyl]isothiazole-4-carbonitrile | 3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]sulfanyl}-5-(2-{[(4-methylbenzyl)oxy]imino}ethyl)-4-isothiazolecarbonitrile | MLS000540003 | SMR000125461 | cid_6035471
Type:
Small organic molecule
Emp. Form.:
C20H14ClF3N4OS2
Mol. Mass.:
482.93
SMILES:
Cc1ccc(CO\N=C/Cc2snc(Sc3ncc(cc3Cl)C(F)(F)F)c2C#N)cc1
Structure:
Search PDB for entries with ligand similarity: