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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM88835
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
28700±3190 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM88835
Synonyms:
(5E)-5-[[3-(dimethylamino)propylamino]methylene]-1-phenethyl-barbituric acid | (5E)-5-[[3-(dimethylamino)propylamino]methylidene]-1-(2-phenylethyl)-1,3-diazinane-2,4,6-trione | 5-[1-(3-Dimethylamino-propylamino)-meth-(E)-ylidene]-1-phenethyl-pyrimidine-2,4,6-trione | MLS000556548 | SMR000147865 | cid_5860995
Type:
Small organic molecule
Emp. Form.:
C18H24N4O3
Mol. Mass.:
344.4082
SMILES:
CN(C)CCCNC=C1C(=O)NC(=O)N(CCc2ccccc2)C1=O |w:7.6|
Structure:
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