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Target26S Proteasome regulatory subunit Rpn11 (Rpn11)
LigandBDBM88839
Substrate/Competitorn/a
Meas. Tech.Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50 4180±290 nM
Citation PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
26S Proteasome regulatory subunit Rpn11 (Rpn11)
Name:26S Proteasome regulatory subunit Rpn11 (Rpn11)
Synonyms:PSMD14 protein
Type:Protein
Mol. Mass.:34576.68
Organism:Homo sapiens (Human)
Description:O00487
Residue:310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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  Blast E-value cutoff:
BDBM88839
NameBDBM88839
Synonyms:(4Z)-4-[(2-methyl-1H-indol-3-yl)methylene]-2-phenyl-2-oxazolin-5-one | (4Z)-4-[(2-methyl-1H-indol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5-one | (4Z)-4-[(2-methyl-1H-indol-3-yl)methylidene]-2-phenyl-5-oxazolone | MLS000536012 | SMR000155333 | cid_5397501
TypeSmall organic molecule
Emp. Form.C19H14N2O2
Mol. Mass.302.3267
SMILESCc1[nH]c2ccccc2c1\C=C1/N=C(OC1=O)c1ccccc1 |c:14|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a