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Target26S Proteasome regulatory subunit Rpn11 (Rpn11)
LigandBDBM83218
Substrate/Competitorn/a
Meas. Tech.Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50 1770±224 nM
Citation PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
26S Proteasome regulatory subunit Rpn11 (Rpn11)
Name:26S Proteasome regulatory subunit Rpn11 (Rpn11)
Synonyms:PSMD14 protein
Type:Protein
Mol. Mass.:34576.68
Organism:Homo sapiens (Human)
Description:O00487
Residue:310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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  Blast E-value cutoff:
BDBM83218
NameBDBM83218
Synonyms:1-[(Z)-3-indolylidenemethyl]-2-(4-nitrophenyl)hydrazine | 1-[(Z)-indol-3-ylidenemethyl]-2-(4-nitrophenyl)diazane | 1-[(Z)-indol-3-ylidenemethyl]-2-(4-nitrophenyl)hydrazine | 1H-indole-3-carbaldehyde (4-nitrophenyl)hydrazone | MLS000573812 | SMR000184664 | cid_5718086
TypeSmall organic molecule
Emp. Form.C15H12N4O2
Mol. Mass.280.2814
SMILES[O-][N+](=O)c1ccc(cc1)N=[NH+]Cc1c[n-]c2ccccc12 |w:10.11|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a