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Target26S Proteasome regulatory subunit Rpn11 (Rpn11)
LigandBDBM51089
Substrate/Competitorn/a
Meas. Tech.Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50 6460±1060 nM
Citation PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
26S Proteasome regulatory subunit Rpn11 (Rpn11)
Name:26S Proteasome regulatory subunit Rpn11 (Rpn11)
Synonyms:PSMD14 protein
Type:Protein
Mol. Mass.:34576.68
Organism:Homo sapiens (Human)
Description:O00487
Residue:310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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BDBM51089
NameBDBM51089
Synonyms:(E)-3-[(3Z)-3-(4-chlorobenzylidene)-2-morpholino-cyclopenten-1-yl]-2-cyano-N-(2-fluorophenyl)acrylamide | (E)-3-[(3Z)-3-[(4-chlorophenyl)methylidene]-2-(4-morpholinyl)-1-cyclopentenyl]-2-cyano-N-(2-fluorophenyl)-2-propenamide | (E)-3-[(3Z)-3-[(4-chlorophenyl)methylidene]-2-morpholin-4-yl-cyclopenten-1-yl]-2-cyano-N-(2-fluorophenyl)prop-2-enamide | (E)-3-[(3Z)-3-[(4-chlorophenyl)methylidene]-2-morpholin-4-ylcyclopenten-1-yl]-2-cyano-N-(2-fluorophenyl)prop-2-enamide | MLS000390081 | SMR000259345 | cid_15945072
TypeSmall organic molecule
Emp. Form.C26H23ClFN3O2
Mol. Mass.463.931
SMILESFc1ccccc1NC(=O)C(=C\C1=C(N2CCOCC2)\C(\CC1)=C/c1ccc(Cl)cc1)\C#N |c:13|
Structure
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n/a