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Target26S Proteasome regulatory subunit Rpn11 (Rpn11)
LigandBDBM50449
Substrate/Competitorn/a
Meas. Tech.Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50 6880±1140 nM
Citation PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
26S Proteasome regulatory subunit Rpn11 (Rpn11)
Name:26S Proteasome regulatory subunit Rpn11 (Rpn11)
Synonyms:PSMD14 protein
Type:Protein
Mol. Mass.:34576.68
Organism:Homo sapiens (Human)
Description:O00487
Residue:310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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BDBM50449
NameBDBM50449
Synonyms:MLS000591126 | N'-[(Z)-3-indolylidenemethyl]-2-[[5-[(4-methylphenyl)methylthio]-1,3,4-thiadiazol-2-yl]thio]acetohydrazide | N'-[(Z)-indol-3-ylidenemethyl]-2-[[5-[(4-methylbenzyl)thio]-1,3,4-thiadiazol-2-yl]thio]acetohydrazide | N'-[(Z)-indol-3-ylidenemethyl]-2-[[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetohydrazide | N'-[(Z)-indol-3-ylidenemethyl]-2-[[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]ethanehydrazide | SMR000218002 | [5-(4-Methyl-benzylsulfanyl)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid [1-(1H-indol-3-yl)-meth-(E)-ylidene]-hydrazide | cid_6506188
TypeSmall organic molecule
Emp. Form.C21H19N5OS3
Mol. Mass.453.603
SMILESCc1ccc(CSc2nnc(SCC(=O)NN=Cc3c[nH]c4ccccc34)s2)cc1 |w:16.15|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a