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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM88918
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
1820±186 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM88918
Synonyms:
MLS001006760 | N-[(E)-1-(1-benzofuran-2-yl)ethylideneamino]-4-nitro-aniline | N-[(E)-1-(1-benzofuran-2-yl)ethylideneamino]-4-nitroaniline | N-[(E)-1-(2-benzofuranyl)ethylideneamino]-4-nitroaniline | SMR000349686 | [(E)-1-(benzofuran-2-yl)ethylideneamino]-(4-nitrophenyl)amine | cid_9658313
Type:
Small organic molecule
Emp. Form.:
C16H13N3O3
Mol. Mass.:
295.2927
SMILES:
C[C-](\N=[NH+]\c1ccc(cc1)[N+]([O-])=O)c1cc2ccccc2o1
Structure:
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