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Target26S Proteasome regulatory subunit Rpn11 (Rpn11)
LigandBDBM60279
Substrate/Competitorn/a
Meas. Tech.Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50 6650±418 nM
Citation PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
26S Proteasome regulatory subunit Rpn11 (Rpn11)
Name:26S Proteasome regulatory subunit Rpn11 (Rpn11)
Synonyms:PSMD14 protein
Type:Protein
Mol. Mass.:34576.68
Organism:Homo sapiens (Human)
Description:O00487
Residue:310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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  Blast E-value cutoff:
BDBM60279
NameBDBM60279
Synonyms:2-bromobenzenecarbothioic acid S-(8-quinolinyl) ester | 2-bromothiobenzoic acid S-(8-quinolyl) ester | MLS001174912 | S-quinolin-8-yl 2-bromanylbenzenecarbothioate | S-quinolin-8-yl 2-bromobenzenecarbothioate | SMR000594785 | cid_1266032
TypeSmall organic molecule
Emp. Form.C16H10BrNOS
Mol. Mass.344.226
SMILESBrc1ccccc1C(=O)Sc1cccc2cccnc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a