Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM60279
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
6650±418 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM60279
Synonyms:
2-bromobenzenecarbothioic acid S-(8-quinolinyl) ester | 2-bromothiobenzoic acid S-(8-quinolyl) ester | MLS001174912 | S-quinolin-8-yl 2-bromanylbenzenecarbothioate | S-quinolin-8-yl 2-bromobenzenecarbothioate | SMR000594785 | cid_1266032
Type:
Small organic molecule
Emp. Form.:
C16H10BrNOS
Mol. Mass.:
344.226
SMILES:
Brc1ccccc1C(=O)Sc1cccc2cccnc12
Structure:
Search PDB for entries with ligand similarity: