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Target26S Proteasome regulatory subunit Rpn11 (Rpn11)
LigandBDBM79219
Substrate/Competitorn/a
Meas. Tech.Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50 6850±434 nM
Citation PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay(2012)[AID]
More Info.:Get all data from this article,  Assay Method
 
26S Proteasome regulatory subunit Rpn11 (Rpn11)
Name:26S Proteasome regulatory subunit Rpn11 (Rpn11)
Synonyms:PSMD14 protein
Type:Protein
Mol. Mass.:34576.68
Organism:Homo sapiens (Human)
Description:O00487
Residue:310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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  Blast E-value cutoff:
BDBM79219
NameBDBM79219
Synonyms:6-cyclopropyl-1-isopropyl-N-(4-sulfamoylphenyl)pyrazolo[3,4-b]pyridine-4-carboxamide | 6-cyclopropyl-1-propan-2-yl-N-(4-sulfamoylphenyl)-4-pyrazolo[3,4-b]pyridinecarboxamide | 6-cyclopropyl-1-propan-2-yl-N-(4-sulfamoylphenyl)pyrazolo[3,4-b]pyridine-4-carboxamide | MLS002171224 | SMR001251521 | cid_9268118
TypeSmall organic molecule
Emp. Form.C19H21N5O3S
Mol. Mass.399.467
SMILESCC(C)n1ncc2c(cc(nc12)C1CC1)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a