Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM88841
Substrate
n/a
Meas. Tech.
Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay
IC50
13100±1690 nM
Citation
 PubChem, PC Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | THRB_BOVIN | Thrombin | Thrombin heavy chain | Thrombin light chain
Type:
Enzyme
Mol. Mass.:
70502.73
Organism:
Bos taurus (Bovine)
Description:
P00735
Residue:
625
Sequence:
MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
  
Inhibitor
Name:
BDBM88841
Synonyms:
2-[5-[(Z)-[4-carbethoxy-3-keto-5-(p-anisidino)-2-thienylidene]methyl]-2-furyl]benzoic acid | 2-[5-[(Z)-[4-ethoxycarbonyl-5-(4-methoxyanilino)-3-oxo-2-thiophenylidene]methyl]-2-furanyl]benzoic acid | 2-[5-[(Z)-[4-ethoxycarbonyl-5-(4-methoxyanilino)-3-oxothiophen-2-ylidene]methyl]furan-2-yl]benzoic acid | 2-[5-[(Z)-[4-ethoxycarbonyl-5-[(4-methoxyphenyl)amino]-3-oxidanylidene-thiophen-2-ylidene]methyl]furan-2-yl]benzoic acid | 2-{5-[(4-(ethoxycarbonyl)-5-(4-methoxyanilino)-3-oxo-2(3H)-thienylidene)methyl]-2-furyl}benzoic acid | MLS000540076 | SMR000162455 | cid_5431846
Type:
Small organic molecule
Emp. Form.:
C26H21NO7S
Mol. Mass.:
491.512
SMILES:
CCOC(=O)C1C(=O)C(SC1=Nc1ccc(OC)cc1)=Cc1ccc(o1)-c1ccccc1C(O)=O |w:11.12,20.22|
Structure:
Search PDB for entries with ligand similarity: