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Target
Tyrosine-protein phosphatase non-receptor type 5
Ligand
BDBM88798
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay
IC50
22900±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay PubChem Bioassay (2012)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 5
Synonyms:
PTN5_HUMAN | PTPN5 | Tyrosine-protein phosphatase non-receptor type 5 | Tyrosine-protein phosphatase non-receptor type 5 isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
63510.68
Organism:
Homo sapiens (Human)
Description:
gi_90652859
Residue:
565
Sequence:
MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLVSSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPEDRRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSHQSPE
  
Inhibitor
Name:
BDBM88798
Synonyms:
2-(2-keto-3,4,8-trimethyl-chromen-7-yl)oxy-N-(4-sulfamoylphenyl)acetamide | MLS001158184 | N-(4-sulfamoylphenyl)-2-(3,4,8-trimethyl-2-oxidanylidene-chromen-7-yl)oxy-ethanamide | N-(4-sulfamoylphenyl)-2-(3,4,8-trimethyl-2-oxochromen-7-yl)oxyacetamide | N-(4-sulfamoylphenyl)-2-[(3,4,8-trimethyl-2-oxo-1-benzopyran-7-yl)oxy]acetamide | SMR000652408 | cid_8035150
Type:
Small organic molecule
Emp. Form.:
C20H20N2O6S
Mol. Mass.:
416.448
SMILES:
Cc1c(C)c(=O)oc2c(C)c(OCC(=O)Nc3ccc(cc3)S(N)(=O)=O)ccc12
Structure:
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