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Target
Dual specificity protein phosphatase 3
Ligand
BDBM88747
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
4940±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88747
Synonyms:
1-(3-methoxypropyl)-1-(1-pyridin-2-ylethyl)-3-(2,4,6-trimethylphenyl)thiourea | 1-(3-methoxypropyl)-1-[1-(2-pyridinyl)ethyl]-3-(2,4,6-trimethylphenyl)thiourea | 3-mesityl-1-(3-methoxypropyl)-1-[1-(2-pyridyl)ethyl]thiourea | MLS000683497 | N'-mesityl-N-(3-methoxypropyl)-N-(1-pyridin-2-ylethyl)thiourea | SMR000311654 | cid_5190551
Type:
Small organic molecule
Emp. Form.:
C21H29N3OS
Mol. Mass.:
371.539
SMILES:
COCCCN(C(C)c1ccccn1)C(=S)Nc1c(C)cc(C)cc1C
Structure:
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