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Target
Dual specificity protein phosphatase 3
Ligand
BDBM88748
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
4180±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM88748
Synonyms:
3-(3-chloranyl-4-methoxy-phenyl)-1-[3-(4-methylpiperidin-1-yl)propyl]-1-(thiophen-2-ylmethyl)thiourea | 3-(3-chloro-4-methoxy-phenyl)-1-[3-(4-methylpiperidino)propyl]-1-(2-thenyl)thiourea | 3-(3-chloro-4-methoxyphenyl)-1-[3-(4-methyl-1-piperidinyl)propyl]-1-(thiophen-2-ylmethyl)thiourea | 3-(3-chloro-4-methoxyphenyl)-1-[3-(4-methylpiperidin-1-yl)propyl]-1-(thiophen-2-ylmethyl)thiourea | MLS000729725 | N'-(3-chloro-4-methoxyphenyl)-N-[3-(4-methylpiperidin-1-yl)propyl]-N-(thien-2-ylmethyl)thiourea | SMR000308002 | cid_16188102
Type:
Small organic molecule
Emp. Form.:
C22H30ClN3OS2
Mol. Mass.:
452.076
SMILES:
COc1ccc(NC(=S)N(CCCN2CCC(C)CC2)Cc2cccs2)cc1Cl
Structure:
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