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Target
Dual specificity protein phosphatase 3
Ligand
BDBM54150
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
3710±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM54150
Synonyms:
2-[2-(4-bromophenyl)-2-oxidanylidene-ethyl]sulfanyl-4-oxidanylidene-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile | 2-[2-(4-bromophenyl)-2-oxoethyl]sulfanyl-4-oxo-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile | 2-[[2-(4-bromophenyl)-2-keto-ethyl]thio]-4-keto-6-(2-thienyl)-1H-pyrimidine-5-carbonitrile | 2-[[2-(4-bromophenyl)-2-oxoethyl]thio]-4-oxo-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile | 2-{[2-(4-bromophenyl)-2-oxoethyl]thio}-6-oxo-4-(2-thienyl)-1,6-dihydropyrimidine-5-carbonitrile | MLS000850710 | SMR000456727 | cid_2727374
Type:
Small organic molecule
Emp. Form.:
C17H10BrN3O2S2
Mol. Mass.:
432.314
SMILES:
Brc1ccc(cc1)C(=O)CSc1nc(-c2cccs2)c(C#N)c(=O)[nH]1
Structure:
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