Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM82999
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
2660±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM82999
Synonyms:
4-acetyl-N-(4-fluorobenzyl)-2,3-dihydro-1,4-benzoxazine-6-sulfonamide | 4-acetyl-N-[(4-fluorophenyl)methyl]-2,3-dihydro-1,4-benzoxazine-6-sulfonamide | 4-ethanoyl-N-[(4-fluorophenyl)methyl]-2,3-dihydro-1,4-benzoxazine-6-sulfonamide | MLS001117284 | SMR000626853 | cid_22519415
Type:
Small organic molecule
Emp. Form.:
C17H17FN2O4S
Mol. Mass.:
364.391
SMILES:
CC(=O)N1CCOc2ccc(cc12)S(=O)(=O)NCc1ccc(F)cc1
Structure:
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