Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89045
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
1480±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89045
Synonyms:
3,4-diethoxybenzoic acid [(Z)-[amino-(4-methoxyphenyl)methylene]amino] ester | 3,4-diethoxybenzoic acid [(Z)-[amino-(4-methoxyphenyl)methylidene]amino] ester | MLS-0454715.0001 | [(Z)-[amino-(4-methoxyphenyl)methylidene]amino] 3,4-diethoxybenzoate | [(Z)-[azanyl-(4-methoxyphenyl)methylidene]amino] 3,4-diethoxybenzoate | cid_9587668
Type:
Small organic molecule
Emp. Form.:
C19H22N2O5
Mol. Mass.:
358.3884
SMILES:
CCOc1ccc(cc1OCC)C(=O)ON=C(N)c1ccc(OC)cc1 |w:15.15|
Structure:
Search PDB for entries with ligand similarity: