Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89048
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
60100±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89048
Synonyms:
4-(1-azepanylsulfonyl)benzoic acid [(Z)-[amino(phenyl)methylidene]amino] ester | 4-(azepan-1-ylsulfonyl)benzoic acid [(Z)-[amino(phenyl)methylene]amino] ester | MLS-0454718.0001 | [(Z)-[amino(phenyl)methylidene]amino] 4-(azepan-1-ylsulfonyl)benzoate | [(Z)-[azanyl(phenyl)methylidene]amino] 4-(azepan-1-ylsulfonyl)benzoate | cid_17558150
Type:
Small organic molecule
Emp. Form.:
C20H23N3O4S
Mol. Mass.:
401.479
SMILES:
NC(=NOC(=O)c1ccc(cc1)S(=O)(=O)N1CCCCCC1)c1ccccc1 |w:2.2|
Structure:
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