Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89054
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
4540±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89054
Synonyms:
2-(2-chlorophenoxy)acetic acid [(Z)-[1-amino-2-(4-chlorophenyl)ethylidene]amino] ester | MLS-0454723.0001 | [(Z)-[1-amino-2-(4-chlorophenyl)ethylidene]amino] 2-(2-chlorophenoxy)acetate | [(Z)-[1-azanyl-2-(4-chlorophenyl)ethylidene]amino] 2-(2-chloranylphenoxy)ethanoate | cid_5343255
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2N2O3
Mol. Mass.:
353.2
SMILES:
Clc1ccc(CC(=N)NOC(=O)COc2ccccc2Cl)cc1
Structure:
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